Active Clinical Trials

October 19, 2020
TMIST accrual bar graph

TMIST Breast Cancer Screening Trial Rebounds from COVID-19 Shutdown of Cancer Screenings

October accrual is on pace to be the highest month on record. Since July 1, TMIST has enrolled more patients than all other National Cancer Institute clinical trials combined. An unheard-of number (nearly 20%) are Black and African American women. Drs. Etta Pisano and Mitch Schnall provide the latest status of the trial and discuss its continuing relevance
October 19, 2020
Blood pressure machine

Now Enrolling: EAQ191 / CARISMA for management of hypertension in patients with metastatic renal cell or thyroid cancer on anti-angiogenic tyrosine kinase inhibitors

This phase II study, led by Dr. Bonnie Ky, aims to generate the necessary data to inform a phase III randomized controlled trial with the potential to make a significant public health impact
September 14, 2020
Lungs

Now Enrolling: EAQ172 for Treatment of Lung Inflammation in Patients with Any Type of Cancer

This phase II trial by EA's Cancer Control and Survivorship Committee is comparing two promising pneumonitis treatments for patients receiving PD-1/PD-L1 therapy
September 14, 2020
Ingrid Mayer, MD

Trial Spotlight: Ingrid Mayer on Study EA1131 for Triple-Negative Breast Cancer, Including Men

This is the only study that is currently designed to test the ability to improve long-term outcomes by refining early-setting triple-negative breast cancer chemotherapy without exposing ALL patients to more toxicity preoperatively
July 29, 2020

Now Enrolling: EA2186 / GIANT for Advanced Pancreas Cancer in Older Adults

Currently, there is no treatment standard for metastatic pancreatic cancer in people aged 65 years and older
June 10, 2020
Lung x-ray on iPad

Now Enrolling: EA5181 for Patients with Stage 3 Non-Small Cell Lung Cancer

This phase III trial is testing the antibody durvalumab added to standard chemoradiation followed by durvalumab for one year, compared to standard chemoradiation followed by one year of the antibody
June 10, 2020
PrECOG logo

Now Enrolling: PrE0905 for Acute Myeloid Leukemia

This phase II study is exploring the potent FLT3 inhibitor gilteritinib
June 10, 2020

The Value of TMIST Compared to Other Breast Cancer Screening Studies

TMIST will provide data that is critical for relating the increased rate of detection of early breast cancers to the clinical outcomes of the screening population
May 29, 2020
Doctor patient CT scan

Now Enrolling: FEATURE (EA1183) – FDG PET to Assess Therapeutic Response in Patients with Bone-dominant Metastatic Breast Cancer

May 29, 2020

NCI’s Natural History Study of COVID-19 in Cancer

The purpose of this trial is to better understand the coronavirus' effect on people with cancer
April 15, 2020
Patient in office

Now Enrolling: EA1181 Decreasing Chemotherapy in HER2 Positive Breast Cancer

For patients who have a pathologic complete response (pCR) after 12 weeks of pre-operative THP (single agent taxane plus trastuzumab and pertuzumab), is it safe to omit additional therapy after surgery?
April 15, 2020
Patient skin exam

Now Enrolling: EA6183 Evaluating Encorafenib and Binimetinib in Metastatic Melanoma

A single-arm phase II trial evaluating the effectiveness of treatment before surgery with encorafenib and binimetinib