Comparing Two Methods to Follow Patients with Pancreatic Cysts

Pancreatic cystic neoplasms occur in up to 20% of the adult population, and prevalence is increasing with more cross-sectional imaging. This trial aims to compare low-intensity and high-intensity surveillance in patients with at least one newly diagnosed pancreatic cyst. The "high" intensity strategy will parallel the Fukuoka guidelines, which recommend frequent follow-up via MRI (every six months to two years) as well as lifelong surveillance and surgery in some cases. The "low" intensity approach will be similar to the American Gastroenterological Association guidelines, which support less frequent follow-up and a higher bar to qualify for surgery. All patients on the trial will be followed for five years.

It is currently unknown which of these two strategies leads to better outcomes. The results of EA2185 may reveal an optimal surveillance strategy, helping to prevent the over- or under-treatment of patients. The study may also uncover findings that could predict the behavior of these cysts.

This study is led by David S. Weinberg, MD, MSc (Fox Chase Cancer Center), pictured.

Learn more about EA2185 at ecog-acrin.org.